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Genetic Factors Affect One's Vulnerability to Fluoride's Adverse Systemic Effects Watch Amanda Sleeper's 5-minute video (Dec. 2019) Also see the videos below:* The profound change in Audrey's autistic son after stopping fluoridated water. Julie's daily migraine headaches stopped after she eliminated fluoride from her diet. Dental fluorosis is the visible evidence of an individual's susceptibility to fluoride toxicity. "Dental fluorosis, no matter how slight, is an irreversible pathological condition recognized by authorities around the world as the first readily detectable clinical symptom of previous chronic fluoride poisoning. To suggest we should ignore such a sign is as irrational as saying that the blue-black line which appears on the gums due to chronic lead poisoning is of no significance because it doesn't cause any pain or discomfort." – New Scientist (1983) Dental fluorosis has mild to severe consequences, but this does not just depend on the amount of fluoride an individual consumes or its concentration in drinking water. Genetic Susceptibility to Fluoride "The role that an individual's genetic background plays in modulating fluoride's actions is becoming more evident." – Fluoride's Effects on the Formation of Teeth and Bones, and the Influence of Genetics (2011) "Severity of dental fluorosis varies individually at the same level of intake." – European Food Safety Authority (2013) "This research provides evidences that there are genetic factors involved in dental fluorosis." – Dalledone et al. (2019) Genetic sensitivity to fluoride's adverse neurological effects was confirmed by researchers who found that children with a variation of the COMT gene, which is associated with cognitive performance, had steeper cognitive decline from exposure to fluoride. – Toxicological Sciences (2015) Last-century's science discovered that fluoride disrupts development of the hardest substance in our body: tooth enamel. This century's science is increasingly discovering that fluoride disrupts development of the most crucial organ in our body: the brain. Defects in tooth enamel have been correlated with impaired brain development. All enamel defects are indications of severe stress, because they result from systemic cellular disruption during prenatal and early postnatal life that can affect other structures, including the brain. Developmental enamel defects in primary teeth have been found at least twice as frequently in children with mental retardation. (Pregnancy and Fluoride Do Not Mix, page 56.) Developmental Defects Increase with Fluoride Levels in Water In fluoridated areas, the prevalence of "cosmetically significant" dental fluorosis is twice as high as in non-fluoridated areas. [The British Fluoridation Society] Journal of Neurochemistry International – October 2016 The autism epidemic may be driven by multiple environmental pollutants via their effects on genetic susceptibility. Suspect candidates include pesticides, heavy metals, and several food additives – including fluoride and other substances on the EPA's list of "developmental neurotoxicants." *Audrey Adams shares a compelling story about her experience of learning about and coping with her autistic son's severe fluoride sensitivity. After taking him off fluoridated water: "There was a profound change in his pain level and thus his behavior just in three days." Watch her 5-minute video. (Dec. 2019) *When Julie Simms eliminated fluoride from her diet: "Within three weeks, that daily migraine headache I'd had for over 10 years was actually gone. I couldn't believe it!" Watch her 4-minute video. (Dec. 2019) 40 million Americans suffer from migraine headache. "Migraine affects three times as many women as men." [CBS News, Feb. 16, 2020] Don't Gamble with Your Children's Future A pregnant woman should avoid fluoride consumption, especially if she has dental fluorosis, visible evidence of her genetic susceptibility to fluoride's developmental toxicity, and her baby's. Black Americans "In this biracial community-based sample, we demonstrate that black race is associated with impaired vascular function compared with whites. Specifically, blacks had reduced microvascular endothelial function... and greater arterial stiffness... even after adjustment for traditional CVD risk factors. Importantly, these differences were present even in the subgroup of participants who were completely free of conventional CVD risk factors." (Morris et al. J Am Heart Assoc. 2013 Endothelial dysfunction and arterial stiffness are two of fluoride's pathological pathways documented in the author's report in the Oct. 2019 Townsend Letter: Fluoride and Mental Decay: Causation & Correlation.